issubclass can take multiple types, so there is no need to call them multiple times for each type.
True if the first argument is an subclass of specified type/types (and a class is considered a subclass of itself).
Given that these result in the same outcome:
Why not choose the easiest to read, write, and execute (the first one)?
Note also that as of Python 3.10,
issubclass also accepts Union Type:
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